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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
THOC2
All Species:
18.79
Human Site:
S1223
Identified Species:
31.79
UniProt:
Q8NI27
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NI27
NP_001075019.1
1593
182775
S1223
A
S
K
S
D
E
S
S
T
E
E
T
D
K
S
Chimpanzee
Pan troglodytes
XP_001139291
1595
183045
S1225
A
S
K
S
D
E
S
S
T
E
E
T
D
K
S
Rhesus Macaque
Macaca mulatta
XP_001086217
1593
182783
S1223
A
S
K
S
D
E
S
S
T
E
E
T
D
K
S
Dog
Lupus familis
XP_538164
1593
182721
S1223
A
S
K
S
D
E
S
S
T
E
E
T
D
K
S
Cat
Felis silvestris
Mouse
Mus musculus
B1AZI6
1594
182755
G1223
A
S
K
S
D
E
S
G
A
E
E
T
D
K
S
Rat
Rattus norvegicus
XP_233081
1594
182711
G1223
A
S
K
S
D
E
S
G
A
E
E
T
D
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510761
1648
188085
T1276
A
A
K
L
E
E
S
T
A
E
E
T
D
K
L
Chicken
Gallus gallus
XP_420332
1593
182430
A1222
T
A
K
L
E
E
S
A
A
E
E
T
D
K
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001003847
1504
172218
N1165
K
V
H
M
V
P
E
N
E
F
H
H
K
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_722763
1641
188490
P1285
D
K
L
S
P
T
S
P
S
G
N
T
Q
G
T
Honey Bee
Apis mellifera
XP_393587
1354
156054
E1016
Y
S
V
T
S
C
T
E
N
E
A
N
R
Y
G
Nematode Worm
Caenorhab. elegans
NP_498392
1437
164369
A1073
R
W
Q
I
R
F
T
A
M
F
K
T
V
F
T
Sea Urchin
Strong. purpuratus
XP_795489
1592
178912
T1222
V
S
S
T
S
N
A
T
V
N
G
V
G
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_173871
1804
205705
G1266
V
N
Q
Q
P
E
S
G
G
L
G
K
D
Q
M
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
99.9
99
N.A.
97.4
97.4
N.A.
85.8
88.1
N.A.
72.9
N.A.
39.7
43.1
29.5
48.7
Protein Similarity:
100
99.3
100
99.3
N.A.
98.9
99
N.A.
91.4
93.9
N.A.
83.4
N.A.
59
60.2
48.5
65.1
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
60
53.3
N.A.
0
N.A.
20
13.3
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
80
73.3
N.A.
13.3
N.A.
33.3
26.6
40
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
15
0
0
0
0
8
15
29
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
43
0
0
0
0
0
0
0
65
0
0
% D
% Glu:
0
0
0
0
15
65
8
8
8
65
58
0
0
8
8
% E
% Phe:
0
0
0
0
0
8
0
0
0
15
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
0
22
8
8
15
0
8
8
8
% G
% His:
0
0
8
0
0
0
0
0
0
0
8
8
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
8
58
0
0
0
0
0
0
0
8
8
8
65
0
% K
% Leu:
0
0
8
15
0
0
0
0
0
8
0
0
0
0
15
% L
% Met:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
8
% M
% Asn:
0
8
0
0
0
8
0
8
8
8
8
8
0
0
0
% N
% Pro:
0
0
0
0
15
8
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
15
8
0
0
0
0
0
0
0
0
8
8
8
% Q
% Arg:
8
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
58
8
50
15
0
72
29
8
0
0
0
0
0
43
% S
% Thr:
8
0
0
15
0
8
15
15
29
0
0
72
0
0
15
% T
% Val:
15
8
8
0
8
0
0
0
8
0
0
8
8
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _